Mechanotransduction mediated cell state reprogramming refers to a multiscale process by which cells interpret physical and structural cues from the extracellular matrix (ECM), including stiffness, topology, and ligand organization, through mechanosensitive receptors such as integrins, and convert these inputs into coordinated intracellular signaling. This process drives the reorganization of cytoskeletal tension, modulation of nuclear mechanics, and rewiring of gene regulatory networks, ultimately leading to a global redefinition of cellular state across molecular, structural, and functional levels.

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